Previous experiments (1) have indicated that Cl. oedematiens toxin produces types of dynamic effects similar to those seen in traumatic shock.Blood volume was not diminished to the same ex- tent as in hemorrhagic shock, but the peripheral vascular resistance rose and the cardiac output was reduced in the characteristic manner.It was not obvious, in the intact dog, whether these difficulties arose in the peripheral circulation or in the heart.Wiggers (2) has discussed a similar type of prob- lem with reference to shock.Thus, in order to evaluate more specifically the factors involved in the circulatory failure resulting from Cl. oede- matiens toxin, the heart-lung preparation has been utilized.
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Krayer et al. (1947) studied this question.