The hepatoprotective and antioxidant effect of broccoli “Brassica oleracea L.” (aqueous extract of freeze dried powder) on liver injury induced by carbon tetrachloride (CCl 4 ) was investigated. Wistar albino rats weighing 180–200 g were administered a single dose of CCl 4 , GOT, GPT, ALP, GGT and bilirubin were estimated in serum. Non-protein sulfhydryl (NP-SH) and malondialdehyde (MDA) were also estimated in liver tissue. CCl 4 induced hepatotoxicity in all treated animals was evident by elevated serum GOT, GPT, ALP, GGT and bilirubin levels and simultaneous fall in NP-SH and increased MDA activities in liver tissue. The broccoli extract at the doses of 150 and 300 mg/kg produced significant hepatoprotection by decreasing the activity of serum enzymes, bilirubin, while it significantly increased the levels of NP-SH and decreased MDA of liver tissue. Histopathological observations of the liver also showed the protective effect of broccoli in CCl 4 -induced hepatic injury in rats. The obtained results suggest that broccoli possesses hepatoprotective capacity and may have potential therapeutic value in the treatment of some liver disorders probably by its antioxidative effects on hepatocytes, due to flavonoids and sulfurated compounds.
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Tawfeq A. Al‐Howiriny (2008) studied this question.
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