Key result
A novel KCNH2 mutation causing inherited long QT syndrome was unmasked by electrolyte disturbance and structural cardiac failure due to peripartum cardiomyopathy, presenting as Torsades de pointes.
Case Report (n=1)
No
A novel KCNH2 mutation associated with long QT syndrome can be unmasked by electrolyte disturbances and structural cardiac failure in peripartum cardiomyopathy, leading to life-threatening Torsades de Pointes.
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May warrant arrhythmia vigilance and genetic evaluation in peripartum cardiomyopathy with TdP; leaves open KCNH2 prevalence and testing utility.
Nishimoto et al. (2012) conducted a case report in Peripartum cardiomyopathy, Torsades de pointes, Long QT Syndrome (n=1). Magnesium sulfate, temporary pacing, and enalapril was evaluated. A novel KCNH2 mutation causing inherited long QT syndrome was unmasked by electrolyte disturbance and structural cardiac failure due to peripartum cardiomyopathy, presenting as Torsades de pointes.
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