Key result
Mulberry leaf extract and its chlorogenic derivatives upregulated caveolin-1 and diminished EGFR/STAT3/iNOS signalling, alleviating alcohol-induced hepatocellular disorders in mice.
Why the study?
Does mulberry leaf extract and its chlorogenic acid derivatives attenuate alcoholic steatohepatitis in a high alcohol-fed mouse model?
Population
High alcohol-fed mouse model
Comparison
Mulberry leaf extract and its major components… vs Control (high alcohol-fed mice without treatment)
Design
Preclinical
Authors
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MLE attenuates alcoholic steatohepatitis in mice; leaves open clinical translation to humans.
Does mulberry leaf extract and its chlorogenic acid derivatives attenuate alcoholic steatohepatitis in a high alcohol-fed mouse model?
Mulberry leaf extract and its chlorogenic acid derivatives attenuate alcoholic steatohepatitis in mice by upregulating caveolin-1 and inhibiting oxidative stress and pro-apoptotic signaling.
Lee et al. (2016) studied Alcoholic steatohepatitis. Mulberry leaf extract (MLE), chlorogenic acid (CGA), and neochlorogenic acid (nCGA) was evaluated on Hepatic injury markers, lipid accumulation, and lipid peroxidation. Mulberry leaf extract and its chlorogenic derivatives upregulated caveolin-1 and diminished EGFR/STAT3/iNOS signalling, alleviating alcohol-induced hepatocellular disorders in mice.