Mitochondrial DNA Mutations and Diabetes: Another Step toward Individualized Medicine

Editorials1 May 2001Mitochondrial DNA Mutations and Diabetes: Another Step toward Individualized MedicineNathan Fischel-Ghodsian, MDNathan Fischel-Ghodsian, MDDr. Fischel-Ghodsian: Cedars-Sinai Medical Center; Los Angeles, CA 90048Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-9_Part_1-200105010-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Twenty years ago, the mitochondrial chromosome was completely sequenced and the functions of all its genes were identified (1). Those genes code for 13 polypeptides, which are part of the more than 60 polypeptides that form the oxidative phosphorylation and adenosine triphosphate synthetase protein complexes in the inner membrane of the mitochondria. In addition, the mitochondrial chromosome codes for two ribosomal RNAs and 22 transfer RNAs, which participate in the translation of the 13 polypeptides on the mitochondrial ribosomes. Each cell contains hundreds of these chromosomes, and they are transmitted only through the ovum, leading to a maternal inheritance pattern. ...References1. Anderson S, Bankier AT, Barrell BG, de Bruijn MH, Coulson AR, Drouin J, et al . Sequence and organization of the human mitochondrial genome. Nature. 1981;290:457-65. [PMID: 7219534] CrossrefMedlineGoogle Scholar2. Ballinger SW, Shoffner JM, Hedaya EV, Trounce I, Polak MA, Koontz DA, et al . Maternally transmitted diabetes and deafness associated with a 10.4 kb mitochondrial DNA deletion. Nat Genet. 1992;1:11-5. [PMID: 1301992] CrossrefMedlineGoogle Scholar3. Reardon W, Ross RJ, Sweeney MG, Luxon LM, Pembrey ME, Harding AE, et al . Diabetes mellitus associated with a pathogenic point mutation in mitochondrial DNA. Lancet. 1992;340:1376-9. 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Google Scholar Author, Article, and Disclosure InformationAuthors: Nathan Fischel-Ghodsian, MDAffiliations: Dr. Fischel-Ghodsian: Cedars-Sinai Medical Center; Los Angeles, CA 90048Acknowledgment: The author thanks Drs. Leslie Raffel, Ricardo Perfetti, and Jerome Rotter for their comments on the editorial.Grant Support: By the National Institutes of Health/National Institute on Deafness and Other Communication Disorders (RO1DC01402 and RO1DC04092).Corresponding Author: Nathan Fischel-Ghodsian, MD, Department of Pediatrics, Suite 1165WT, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMaternally Inherited Diabetes and Deafness: A Multicenter Study Pierre-Jean Guillausseau , Pascale Massin , Danièle Dubois-LaForgue , José Timsit , Marie Virally , Henri Gin , Eric Bertin , Jean-Frédéric Blickle , Béatrice Bouhanick , Juliette Cahen , Sophie Caillat-Zucman , Guillaume Charpentier , Pierre Chedin , Christèle Derrien , Pierre-Henri Ducluzeau , André Grimaldi , Bruno Guerci , Edgar Kaloustian , Arnaud Murat , Frédérique Olivier , Michel Paques , Véronique Paquis-Flucklinger , Béatrice Porokhov , Julien Samuel-Lajeunesse , and Bernard Vialettes Maternally Inherited Diabetes and Deafness: A Multicenter Study Pierre-Jean Guillausseau , Pascale Massin , Danièle Dubois-LaForgue , José Timsit , Marie Virally , Henri Gin , Eric Bertin , Jean-Frédéric Blickle , Béatrice Bouhanick , Juliette Cahen , Sophie Caillat-Zucman , Guillaume Charpentier , Pierre Chedin , Christèle Derrien , Pierre-Henri Ducluzeau , André Grimaldi , Bruno Guerci , Edgar Kaloustian , Arnaud Murat , Frédérique Olivier , Michel Paques , Véronique Paquis-Flucklinger , Béatrice Porokhov , Julien Samuel-Lajeunesse , and Bernard Vialettes Metrics Cited byIndividualized medicine, health medicine, and constitutional theory in Chinese medicinemt-Nd2 Allele of the ALR/Lt mouse confers resistance against both chemically induced and autoimmune diabetesMitochondrial DiseasesTowards Integrative postmodern individualized medicine in terms of hierarchic emergenceHereditäre NierenerkrankungenDevelopment of lipophilic cations as therapies for disorders due to mitochondrial dysfunctionHereditäre Nierenerkrankungen 1 May 2001Volume 134, Issue 9_Part_1Page: 777-779KeywordsBlood cellsChromosomesDeafnessHearingInsulin secretionMitochondrial DNAMutationPhenotypesPolypeptidesType 2 diabetes ePublished: 1 May 2001 Issue Published: 1 May 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. 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