Micropeptins 478-A and -B, plasmin inhibitors, were isolated from the cultured cyanobacterium Microcystis aeruginosa (NIES-478). Their structures were elucidated to be 1 and 2 on the basis of 2D NMR data and chemical degradation. These cyclic depsipeptides inhibited plasmin potently with IC 50 of 0.1 and 0.4 μg/mL, respectively.
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Ishida et al. (1997) studied this question.
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