What does this research mean for the field?

Glucosamine-functionalized multi-walled carbon nanotubes loaded with antibiotics significantly enhance antibacterial efficacy against resistant strains while demonstrating lower cytotoxicity to human cells compared to free drugs. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To develop and evaluate glucosamine-functionalized multi-walled carbon nanotubes as nanocarriers to improve the delivery, potency, and safety of antibiotics against resistant bacteria.

September 8, 2026International MicrobiologyOpen Access

Glucosamine functionalized multi-walled carbon nanotubes as potential antibacterial molecules

View Full Paper

Ask AI

Bookmark

Authors

NANoor AkbarNational Institute for Biotechnology and Genetic Engineering JGJasra GulUniversity of Karachi RSRuqaiyyah SiddiquiHeriot-Watt University

Discussion

Member takes

Overview

In vitro study shows enhanced antibacterial efficacy and low cytotoxicity from glucosamine-functionalized carbon nanotubes, indicating potential for tackling multidrug-resistant infections.

Key Points

To develop and evaluate glucosamine-functionalized multi-walled carbon nanotubes as nanocarriers to improve the delivery, potency, and safety of antibiotics against resistant bacteria.
Multi-walled carbon nanotubes were oxidized, functionalized with glucosamine, and loaded with ethacridine lactate or sulfamethoxazole.
Nanoconjugates were characterized using thermogravimetric analysis, Fourier transform infrared spectroscopy, scanning electron microscopy, UV-Vis spectroscopy, and dynamic light scattering.
Antibacterial activity was assessed against Gram-negative and Gram-positive strains, alongside cytotoxicity evaluations in human endothelial cells (HBEC-5i).
Nanoconjugates exhibited encapsulation efficiencies of 85.37% for ethacridine lactate and 93.69% for sulfamethoxazole, with hydrodynamic diameters from 127 to 429 nm and zeta potentials of -17 to -23 mV.
The ethacridine lactate nanoconjugate achieved 100% bacterial inhibition across all tested strains, with IC₅₀ values of 10.20 ± 0.19 µg/mL against E. coli K1 and 10.74 ± 0.05 µg/mL against S. pneumoniae.
Drug-loaded nanoconjugates demonstrated low cytotoxicity in HBEC-5i endothelial cells in contrast to the substantial toxicity produced by free antibiotics alone.

Cite This Study

Akbar et al. (2026) studied this question.

synapsesocial.com/papers/6a9fd74958e84d0ff5b45d76 https://doi.org/10.1007/s10123-026-00889-y

View Full Paper

Ask AI

Bookmark

September 8, 2026International MicrobiologyOpen Access

Glucosamine functionalized multi-walled carbon nanotubes as potential antibacterial molecules

View Full Paper

Ask AI

Bookmark

Authors

NANoor AkbarNational Institute for Biotechnology and Genetic Engineering JGJasra GulUniversity of Karachi RSRuqaiyyah SiddiquiHeriot-Watt University

Discussion

Member takes

Overview

In vitro study shows enhanced antibacterial efficacy and low cytotoxicity from glucosamine-functionalized carbon nanotubes, indicating potential for tackling multidrug-resistant infections.

Key Points

To develop and evaluate glucosamine-functionalized multi-walled carbon nanotubes as nanocarriers to improve the delivery, potency, and safety of antibiotics against resistant bacteria.
Multi-walled carbon nanotubes were oxidized, functionalized with glucosamine, and loaded with ethacridine lactate or sulfamethoxazole.
Nanoconjugates were characterized using thermogravimetric analysis, Fourier transform infrared spectroscopy, scanning electron microscopy, UV-Vis spectroscopy, and dynamic light scattering.
Antibacterial activity was assessed against Gram-negative and Gram-positive strains, alongside cytotoxicity evaluations in human endothelial cells (HBEC-5i).
Nanoconjugates exhibited encapsulation efficiencies of 85.37% for ethacridine lactate and 93.69% for sulfamethoxazole, with hydrodynamic diameters from 127 to 429 nm and zeta potentials of -17 to -23 mV.
The ethacridine lactate nanoconjugate achieved 100% bacterial inhibition across all tested strains, with IC₅₀ values of 10.20 ± 0.19 µg/mL against E. coli K1 and 10.74 ± 0.05 µg/mL against S. pneumoniae.
Drug-loaded nanoconjugates demonstrated low cytotoxicity in HBEC-5i endothelial cells in contrast to the substantial toxicity produced by free antibiotics alone.

Cite This Study

Akbar et al. (2026) studied this question.

synapsesocial.com/papers/6a9fd74958e84d0ff5b45d76 https://doi.org/10.1007/s10123-026-00889-y

View Full Paper

Ask AI

Bookmark