Experimental study demonstrates relative stereochemical determination in flexible saturated heterocycles using a cage-based crystalline sponge method, highlighting an alternative to NMR analysis.
We present a cage-based crystalline sponge method as a practical strategy for the relative stereochemical determination of flexible saturated heterocycles that are not amenable to nuclear magnetic resonance analysis. Validated using a bis-tetrahydrofuran series and complex bioactives, this method offers a robust solution for resolving stereochemical ambiguities in conformationally flexible molecular systems.
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Yu et al. (2026) studied this question.
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