What does this research mean for the field?

A modest number of mutations is sufficient to accurately reconstruct clonal tree topologies, validating mutation subsampling as an effective strategy for managing large-scale phylogenetic datasets. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To determine the theoretical and empirical number of mutations required to accurately reconstruct clonal lineage tree topologies using subsampling methods.

September 8, 2026Bioinformatics AdvancesOpen Access

Theoretical estimates on the expected number of mutations needed to reconstruct clonal lineage trees

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Authors

NBNishat Anjum BristyCarnegie Mellon University RSRussell SchwartzCarnegie Mellon University

Discussion

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Implication

Computational study reveals that subsampling modest numbers of mutations accurately reconstructs clonal lineage trees, highlighting a scalable strategy for massive single-cell genomic datasets.

Key Points

To determine the theoretical and empirical number of mutations required to accurately reconstruct clonal lineage tree topologies using subsampling methods.
Theoretically analyzed mathematical variants of standard phylogenetic models underlying clonal lineage tree reconstruction tools to derive mutation bounds.
Validated theoretical bounds using synthetic simulations of somatic evolutionary models alongside real biological sequencing datasets via an open-source Python pipeline.
Demonstrated that surprisingly modest numbers of mutations are mathematically sufficient to reconstruct true clonal tree topologies across typical clone counts.
Showed that subsampling mutations to generate an initial guide tree followed by rapid placement of remaining mutations resolves scalability bottlenecks in single-cell cancer phylogenetics.

Cite This Study

Bristy et al. (2026) studied this question.

synapsesocial.com/papers/6a9fd7b758e84d0ff5b46954 https://doi.org/10.1093/bioadv/vbag264

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September 8, 2026Bioinformatics AdvancesOpen Access

Theoretical estimates on the expected number of mutations needed to reconstruct clonal lineage trees

View Full Paper

Ask AI

Bookmark

Authors

NBNishat Anjum BristyCarnegie Mellon University RSRussell SchwartzCarnegie Mellon University

Discussion

Member takes

Implication

Computational study reveals that subsampling modest numbers of mutations accurately reconstructs clonal lineage trees, highlighting a scalable strategy for massive single-cell genomic datasets.

Key Points

To determine the theoretical and empirical number of mutations required to accurately reconstruct clonal lineage tree topologies using subsampling methods.
Theoretically analyzed mathematical variants of standard phylogenetic models underlying clonal lineage tree reconstruction tools to derive mutation bounds.
Validated theoretical bounds using synthetic simulations of somatic evolutionary models alongside real biological sequencing datasets via an open-source Python pipeline.
Demonstrated that surprisingly modest numbers of mutations are mathematically sufficient to reconstruct true clonal tree topologies across typical clone counts.
Showed that subsampling mutations to generate an initial guide tree followed by rapid placement of remaining mutations resolves scalability bottlenecks in single-cell cancer phylogenetics.

Cite This Study

Bristy et al. (2026) studied this question.

synapsesocial.com/papers/6a9fd7b758e84d0ff5b46954 https://doi.org/10.1093/bioadv/vbag264

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