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September 8, 2026Microbiology ResearchOpen Access

Distribution of HLA-G Alleles and Oncogenic Viruses in Laryngeal Squamous Cell Carcinoma

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Authors

LBLjiljana BožićAŠAleksandra ŠmitranMTMaja Travar

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Overview

Cross-sectional tissue study finds frequent HPV and EBV co-infection without HLA-G allele correlation in laryngeal squamous cell carcinoma, highlighting independent viral oncogenesis.

Key Points

  • To investigate the distribution of HLA-G alleles and their potential association with oncogenic viruses in laryngeal squamous cell carcinoma tissues.
  • Analyzed N=30 frozen laryngeal squamous cell carcinoma tissue specimens.
  • Identified and genotyped HPV and EBV via nested PCR and direct sequencing, alongside semi-nested PCR for BKPyV and JCPyV.
  • HLA-G*01:01:01 predominated among the six detected alleles (p < 0.001).
  • Viral DNA was identified for HPV (12/30), EBV (11/30), BKPyV (2/30), and JCPyV (0/30), with high-risk HPV strains significantly outnumbering low-risk types (p = 0.01) and HPV/EBV co-infection predominating (p = 0.03).
  • No statistically significant correlation was observed between specific HLA-G alleles and the presence of single or viral co-infections.

Cite This Study

Božić et al. (2026) studied this question.

synapsesocial.com/papers/6a9fd7d558e84d0ff5b46e68https://doi.org/10.3390/microbiolres17090173
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