Key result
Aloin inhibited lipopolysaccharide-induced barrier disruption, cell adhesion molecule expression, leukocyte migration, and lethality in endothelial cells and mice.
Aloin may attenuate endothelial inflammation in vitro; leaves open clinical translation pending in vivo and human studies.
species. Here, the anti-inflammatory functions of aloin against lipopolysaccharide (LPS)-induced vascular inflammatory responses were tested in endothelial cells or mice such as permeability, expressions of cell adhesion molecule (CAM), migration of leukocytes and lethality. Aloin was found to inhibit LPS-induced barrier disruption, CAM expression, and neutrophil adhesion/transendothelial migration to endothelial cells. Furthermore, aloin inhibited LPS-induced hyperpermeability, leukocyte migration, lethality in vivo. These results suggest that aloin has anti-inflammatory activities against LPS, thereby supporting its usefulness as a treatment for vascular inflammatory.
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Lee et al. (2022) studied Lipopolysaccharide (LPS)-induced vascular inflammatory responses. Aloin was evaluated on LPS-induced barrier disruption, CAM expression, neutrophil adhesion/transendothelial migration, hyperpermeability, leukocyte migration, and lethality. Aloin inhibited lipopolysaccharide-induced barrier disruption, cell adhesion molecule expression, leukocyte migration, and lethality in endothelial cells and mice.
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