Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 8, 2026Clinical Kidney JournalOpen Access

Complete recovery of thrombotic microangiopathy with severe acute kidney injury due to intravenous use of modified release oxycodone

View Full Paper
Ask AI
Bookmark
Share

Authors

MEMoses EzeakileTZTasnim Zirapury

Discussion

Loading...

Member takes

Overview

Case report demonstrates complete renal recovery following cessation of intravenous modified-release oxycodone in anuric kidney failure, suggesting drug withdrawal alone resolves severe toxicity.

Key Points

  • To report a case of thrombotic microangiopathy with anuric acute kidney injury requiring dialysis induced by intravenous modified-release oxycodone and evaluate the efficacy of drug cessation alone.
  • Clinical evaluation of a patient presenting with anuric acute kidney injury and thrombotic microangiopathy following intravenous administration of tamper-resistant modified-release oxycodone (OxyContin).
  • Management via drug withdrawal, supportive therapy, and hemodialysis without initiating invasive interventions such as therapeutic plasma exchange.
  • The patient achieved complete renal recovery and resolution of thrombotic microangiopathy following the discontinuation of intravenous oxycodone.
  • Supportive management and cessation of the offending agent were sufficient to reverse severe, dialysis-dependent acute kidney injury without invasive therapies.

Cite This Study

Ezeakile et al. (2026) studied this question.

synapsesocial.com/papers/6a9fd81458e84d0ff5b473e5https://doi.org/10.1093/ckj/sfag292
View Full Paper
Ask AI
Bookmark
Share