Key result
Doxorubicin administration during prepuberty causes functional and morphological late damage to Sertoli cells, contributing to enhanced spermatogenic harm.
Population
60 male Wistar rats (Rattus norvegicus albinus), prepubertal (15 days postpartum at start of study)
Comparison
Doxorubicin 5 mg/Kg total dose via… vs 0.9% saline solution at the same ages and volume
Design
Preclinical
Follow-up
up to 127 days postpartum
Authors
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Prepubertal doxorubicin exposure warrants fertility monitoring in survivors; animal data leave open human validation of Sertoli-targeted protection.
Doxorubicin administration during prepuberty causes late functional and morphological damage to Sertoli cells in rats, secondary to germ cell injury.
Brilhante et al. (2012) studied Healthy prepubertal rats (n=60). Doxorubicin vs. 0.9% saline solution was evaluated on Sertoli cell morphology and function (transferrin labeling and seminiferous epithelium cycle stages). Doxorubicin administration during prepuberty causes functional and morphological late damage to Sertoli cells, contributing to enhanced spermatogenic harm.
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