A profitable split: An organocatalytic resolution converts readily available racemic oxazinones 1 into valuable enantiomerically pure β-amino acid derivatives 2 (>99 % ee of the remaining 1 at 53 % conversion; 88 % ee of the ester 2). This catalytic ring-opening reaction requires as little as 1 mol % of the modular and readily accessible thiourea organocatalyst 3.
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Berkessel et al. (2005) studied this question.