Over 99 % ee was obtained for all the tested substrates in a Rh-catalyzed Alder–ene reaction. Simply mixing air-stable, commercially available [{Rh(cod)Cl}2] (cod=1,5-cyclooctadiene) and 2,2′-bis(diphenylphosphanyl)-1,1′-binaphthyl (binap) at room temperature afforded functionalized and chiral tetrahydrofurans in high yields with high efficiency (turnover frequency: 1500 h−1). The catalyst loading was as low as 0.8 mol %.
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Lei et al. (2002) studied this question.