All articles of this category A key step in the synthesis of (3 R *,4 R *)-Luffariolide E is a 1,2-metallate rearrangement of a higher order cuprate to generate a trisubstituted double bond stereoselectively. The synthetic product is a diastereoisomer of the natural marine cytotoxic agent (3 S ,4 R )-Luffariolide E. radical cyclisation - metallate rearrangement - organocuprate - trisubstituted alkene - marine cytotoxin - sesterterpenoid
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Hareau-Vittini et al. (1995) studied this question.
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