Key result
A homology model of PMP22 suggests that several mutations causing peripheral neuropathy act by disrupting transmembrane helix packing interactions.
A homology model of PMP22 suggests that neuropathy-causing missense mutations disrupt transmembrane helix packing interactions.
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Model of PMP22 mutations disrupting helix packing leaves open functional validation before informing neuropathy therapies.
Mittendorf et al. (2014) studied Peripheral neuropathy. Homology modeling of PMP22 was evaluated on Transmembrane helix packing interactions. A homology model of PMP22 suggests that several mutations causing peripheral neuropathy act by disrupting transmembrane helix packing interactions.
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