The physical properties of nonaqueous triglyceride/-unsaturated C18 fatty alcohol/methanol systems were studied to determine the suitability of six different fatty alcohols as solubility enhancers. The affects of the degree of unsaturation and the configuration of the double bonds in the amphiphilic tailgroup were examined. Miscibility studies revealed that these amphiphiles can significantly increase the solubility of methanol in triglyceride oils. Under most conditions, kinematic viscosity and interfacial tension results indicated that formation of large aggregates in triglyceride-solvent was unlikely. However, viscosity data for triolein/9Z-octadecen-l-ol/methanol solutions with a high methanol content may indicate that a nonaqueous microemulsion system was forming. Finally, the results could not rule out the formation of pre-micellar aggregates in any of the systems.
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Dunn et al. (1992) studied this question.
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