Polymorphs of a 1:1 Cocrystal with Tunnel and Layer Structures: p,p‘-Biphenol/Dimethyl Sulfoxide

Two polymorphs of the 1:1 cocrystal formed between p, p ‘-biphenol and dimethyl sulfoxide (DMSO) have been discovered. One polymorph has a tunnel type structure, which can be considered to comprise tunnels formed from p, p ‘-biphenol molecules accommodating the DMSO molecules as guests. The other polymorph has a layered structure, comprising layers of p, p ‘-biphenol molecules and layers of DMSO molecules. In both structures, there is direct hydrogen bonding between the p, p ‘-biphenol and DMSO components of the cocrystal. The general utility of the p, p ‘-biphenol molecule as a component in crystal engineering strategies is discussed.