Answers are grounded in this paper and cite their sources.
An automated crystallization platform enabled by FTIR and FBRM in combination with automation and chemometrics has provided a versatile tool for efficient crystallization process development. This system allows users to perform a “walkup” operation for routine process evaluation and also execute automated feedback control of crystallization based on a preset supersaturation profile via cooling and/or antisolvent addition. The concept, procedure, and benefits of the PAT-enabled crystallization platform are presented in general terms and then illustrated through several case studies where feedback control is applied to cooling, antisolvent addition, and “fed batch” (hot batch solution charged to lower-temperature seed bed) crystallization.
No takes yet. Share an insight, caveat, or question.
Zhou et al. (2013) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: