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Preparations of polyoma virus purified by CsCl isodensity centri'fugation stained yellow green at pH 3.8 with 0.01% acridine orange. Pretreatment with a proteolytic enzyme was necessary before development of the stain could be inhibited by DNAase. RNAase had no effect on similar preparations. These characteristics are consistent with the identification of the nucleic acid of polyoma virus as a double-stranded DNA.
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Heather D. Mayor (1961) studied this question.
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