A mutant of diphtheria toxin in which Ile-364 was replaced by Lys was at least 500-fold less toxic to Vero cells than the parental toxin. Its ability to undergo low-pH-triggered translocation across the plasma membrane was greatly diminished, as was its ability to form ion-conductive channels. In addition, the mutant toxin was inactive in the pH-dependent killing of Escherichia coli.
No takes yet. Share an insight, caveat, or question.
Cabiaux et al. (1993) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: