Key result
Prone sleep position is more strongly associated with SIDS during the day, whereas maternal smoking and illness are associated with night-time deaths, suggesting at least two distinct SIDS subtypes.
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Circadian variation in SIDS risk factors suggests the existence of at least two distinct SIDS subtypes with different underlying mechanisms.
UNLABELLED: Sudden infant death syndrome (SIDS) is known to occur more frequently at night. In two studies it has now been shown that a prone sleep position is more strongly associated with SIDS occurring during the day, whereas night-time deaths are more strongly associated with maternal smoking and illness. CONCLUSION: This variation, although unexplained, does suggest at least two SIDS subtypes: one related to sleep position and possibly a thermal mechanism, and one related to an uncontrolled inflammatory response to infection predominantly occurring at night. In addition, there are probably other mechanisms that do not show a circadian variation.
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Mitchell et al. (2003) conducted a review in Sudden infant death syndrome (SIDS). Circadian variation in risk factors was evaluated on SIDS subtypes. Prone sleep position is more strongly associated with SIDS during the day, whereas maternal smoking and illness are associated with night-time deaths, suggesting at least two distinct SIDS subtypes.
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