June 1, 1978Journal of Heterocyclic Chemistry

A side reaction encountered in using the peptide coupling reagent N‐ethoxycarbonyl‐2‐ethoxy‐1,2‐dihydroquinoline (EEDQ)

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JLJoseph G. LombardinoSimmons University SASusan AndersonTharawal Aboriginal CNCharles P. Norris

Abstract

An unusual side reaction has been found during an attempt to form an amide link between 2‐aminothiazole and thiophene‐2‐carboxylic acid in the presence of EEDQ. Ethyl N‐(‐thiazolyl)‐carbamate (3) was isolated in significant amounts indicating that 2‐aminothiazole, and perhaps other heterocyclic amines, can react directly with EEDQ to form carbamates.

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Lombardino et al. (1978) studied this question.

synapsesocial.com/papers/6a9fed3ad40bd26775e61bee https://doi.org/10.1002/jhet.5570150426

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A side reaction encountered in using the peptide coupling reagent N‐ethoxycarbonyl‐2‐ethoxy‐1,2‐dihydroquinoline (EEDQ)

Abstract

Discussion

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Cite This Study

A side reaction encountered in using the peptide coupling reagent N‐ethoxycarbonyl‐2‐ethoxy‐1,2‐dihydroquinoline (EEDQ)

Abstract

Discussion

Member takes

Cite This Study

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