The dye-salt formation method was successfully applied to the determination of chlorpheniramine maleate and chlorphenoxamine hydrochloride each in presence of caffeine. At pH 5, the chromogens (λmax=420 nm) produced with methyl orange in chloroform obeyed Beer's law over the range 5-15 ug/ml and with relative SD less than 1%.
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Barary et al. (1991) studied this question.
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