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Bioassay-directed fractionation of a butanol-soluble fraction of methanol extract of the root of Achyranthes bidentata resulted in the isolation of 5 new oleanolic acid glycosides 1 - 5 , namely, 18-(β- D -glucopyranosyloxy)-28-oxoolean-12-en-3β-yl 3- O -(β- D -glucopyranosyl)-β- D -glucopyranosiduronic acid methyl ester ( 1 ), achyranthoside C dimethyl ester ( 2 ), achyranthoside C butyl dimethyl ester ( 3 ), achyranthoside E dimethyl ester ( 4 ), and achyranthoside E butyl methyl ester ( 5 ), together with 10 known compounds. Their structures were established on the basis of spectroscopic interpretation and chemical methods. All the oleanolic acid glycosides inhibited the formation of osteoclast-like multinucleated cells (OCLs) induced by 1α,25(OH) 2 D 3 in a co-culture assay system. Abbreviations OA:oleanolic acid (OA) GlcA:glucuronic acid CC:column chromatography 1α,25(OH) 2 D 3 :1α,25-dihydroxyvitamin D 3 FBS:fetal bovine serum α-MEM:minimum essential medium PTH:parathyroid hormone OCL:osteoclast-like multinucleated cell
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Li et al. (2005) studied this question.
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