Correlation of Renal Biopsy and Radionuclide Renal Scan Differential Function in Patients with Unilateral Ureteropelvic Junction Obstruction

No AccessJournal of UrologyHydronephrosis: Clinical1 Aug 1995Correlation of Renal Biopsy and Radionuclide Renal Scan Differential Function in Patients with Unilateral Ureteropelvic Junction Obstruction Jeffrey A.* Stock, Henry F. Krous, John Heffernan, Michael Packer, and George W. Kaplan Jeffrey A.* StockJeffrey A.* Stock More articles by this author , Henry F. KrousHenry F. Krous More articles by this author , John HeffernanJohn Heffernan More articles by this author , Michael PackerMichael Packer More articles by this author , and George W. KaplanGeorge W. Kaplan More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)67142-8AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail To understand better the relationship among radionuclide renal scan differential function, renal histology and the outcome of pyeloplasty we performed ipsilateral renal biopsies in a series of patients undergoing primary pyeloplasty. A total of 17 consecutive patients with unilateral ureteropelvic junction obstruction underwent renal biopsy at the time of pyeloplasty. Biopsies were examined systematically after sections were stained with hematoxylin and eosin, periodic acid, Schiff, Jones modified silver or Masson trichrome stains, and they were reviewed by 1 pathologist. Biopsy results were correlated with preoperative and postoperative radionuclide renal scan differential functions. Patient age ranged from 1 month to 7 years (mean 19.8 months). Renal biopsy was abnormal in 6 kidneys, of which 5 had a preoperative differential function of less than 33 percent. None of these kidneys had evidence of postoperative improvement in renal function on followup scans despite a technically successful result. All remaining 11 kidneys had normal biopsies and a preoperative differential function of greater than 44 percent. We conclude from these data that patients with ureteropelvic junction obstruction with a differential function of less than 35 percent have a high probability of significant histological changes on biopsy and a low probability of postoperative improvement in differential function. References 1 : Problems in the diagnosis of obstruction in the neonate.. In: Urologic Surgery in Neonates and Young Infants. Edited by . Philadelphia: W. B. Saunders Co.1988: 77. chapt. 5. Google Scholar 2 : Grading nephroureteral dilatation detected in the first year of life: correlation with obstruction. J. Urol.1992; 148: 609. Link, Google Scholar 3 : Outcome analysis of pediatric pyeloplasty as a function of age, presentation and differential renal function. J. Urol., part 21994; 151: 328A. abstract 401. Google Scholar 4 : Ureteral structure and ultrastructure. Part II. Congenital ureteropelvic junction obstruction and primary obstructive megaureter. J. Urol.1976; 116: 725. Link, Google Scholar 5 : Microanatomy and morphometry of the hydronephrotic “obstructed” renal pelvis in asymptomatic infants. J. Urol.1992; 148: 519. Link, Google Scholar 6 : The pathophysiology of urinary tract obstruction. In: . Philadelphia: W. B. Saunders Co.1992: 497. chapt. 11. Google Scholar 7 : Experimental partial ureteric obstruction in newborn rats. VII. Are the long term effects on renal morphology avoided by release of the obstruction?. J. Urol.1986; 136: 1330. Link, Google Scholar 8 : Histologic renal parenchymal changes secondary to UPJ obstruction. J. Urol., part 21993; 149: 224A. abstract 41. Google Scholar 9 : Structural-functional correlations in renal disease. II. The correlations. Hum. Path.1970; 1: 631. Google Scholar 10 : Significance of tubulointerstitial changes in the renal cortex for excretory function and concentration ability of the kidney: a morphometric contribution. Amer. J. Nephrol.1987; 7: 421. Google Scholar Children's Hospital and Health Center, and Departments of Surgery (Division of Urology), Pathology and Pediatrics, University of California at San Diego Medical Center, San Diego, California.© 1995 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byBandin F, Siwy J, Breuil B, Mischak H, Bascands J, Decramer S and Schanstra J (2012) Urinary Proteome Analysis at 5-Year Followup of Patients With Nonoperated Ureteropelvic Junction Obstruction Suggests Ongoing Kidney RemodelingJournal of Urology, VOL. 187, NO. 3, (1006-1011), Online publication date: 1-Mar-2012.Kajbafzadeh A, Elmi A, Talab S, Emami H, Esfahani S and Saeedi P (2010) Urinary and Serum Carbohydrate Antigen 19-9 as a Biomarker in Ureteropelvic Junction Obstruction in ChildrenJournal of Urology, VOL. 183, NO. 6, (2353-2360), Online publication date: 1-Jun-2010.BOUBAKER A, PRIOR J, MEYRAT B and DELALOYE A (2018) Unilateral Ureteropelvic Junction Obstruction in Children: Long-Term Followup After Unilateral PyeloplastyJournal of Urology, VOL. 170, NO. 2, (575-579), Online publication date: 1-Aug-2003.LAMA G, FERRARACCIO F, IACCARINO F, LUONGO I, MARTE A, RAMBALDI P and ESPOSITO-SALSANO M (2018) Pelviureteral Junction Obstruction: Correlation of Renal Cell Apoptosis and Differential Renal FunctionJournal of Urology, VOL. 169, NO. 6, (2335-2338), Online publication date: 1-Jun-2003.HAN S, LEE S, KIM J, JEONG H, RHA K and CHOI S (2018) DOES DELAYED OPERATION FOR PEDIATRIC URETEROPELVIC JUNCTION OBSTRUCTION CAUSE HISTOPATHOLOGICAL CHANGES?Journal of Urology, VOL. 160, NO. 3 Part 2, (984-988), Online publication date: 1-Sep-1998.PASCUAL L, OLIVA J, VEGA-P. J, PRINCIPI I and VALLES P (2018) RENAL HISTOLOGY IN URETEROPELVIC JUNCTION OBSTRUCTION: ARE HISTOLOGICAL CHANGES A CONSEQUENCE OF HYPERFILTRATION?Journal of Urology, VOL. 160, NO. 3 Part 2, (976-979), Online publication date: 1-Sep-1998. Volume 154Issue 2August 1995Page: 716-718 Advertisement Copyright & Permissions© 1995 by American Urological Association, Inc.Metrics Author Information Jeffrey A.* Stock More articles by this author Henry F. Krous More articles by this author John Heffernan More articles by this author Michael Packer More articles by this author George W. Kaplan More articles by this author Expand All Advertisement PDF downloadLoading ...