Amelioration of toxicopathological effects of thiamethoxam in broiler birds with vitamin E and selenium

This study investigated that to which extent selenium and vitamin E ameliorate toxic effects of thiamethoxam (TMX) in broiler birds. A total of (n = 100) chicks were divided into five equal groups. Sub-lethal doses of TMX 100 mg/kg BW were administered through crop tubing to groups A to D. Broiler chicks in groups B and C were supplemented with vitamin E (@150 mg/kg of BW) and selenium (@ 0.25 mg/kg of BW), respectively, through drinking water. Group D was supplemented with both antioxidants (vitamin E and selenium) whereas Group E served as a control. Blood samples from five birds of each group were collected at 14th, 28th, and 42nd days for hemato-biochemical studies. TMX treated birds showed clinical signs of respiratory, digestive, nervous, and behavioral upsets. TMX treated broilers exhibited a significant (p < 0.05) decrease in hematological indices like TEC, TLC, Hb, PCV, MCH, and MCHC. Biochemical parameters like TP, globulin, and albumin were decreased significantly while a significant (P <0.05) increase was observed in other parameters including such as AST, ALT, GGT, BUN, and creatinine. However, beneficial effects of combination of Vit E and selenium have been observed on hemato-biochemical parameters. It was concluded that TMX induces toxicopathological effects on hemato-biochemical parameters in broiler chicks which can be partially ameliorated by selenium and vitamin E.