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February 9, 2018Human Vaccines & ImmunotherapeuticsOpen Access

IgA polymerization contributes to efficient virus neutralization on human upper respiratory mucosa after intranasal inactivated influenza vaccine administration

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Authors

YTYoshihiko TerauchiKochi Medical School HospitalKSKaori SanoNational Institute of Infectious DiseasesAAAkira AinaiNational Institute of Infectious Diseases

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Implication

Clinical evaluation reveals that intranasal influenza vaccination induces multimeric IgA antibodies in human nasal mucosa, indicating improved virus neutralization through enhanced antigen binding.

Key Points

  • Determine whether a two-dose intranasal inactivated influenza vaccine induces protective multimeric IgA antibodies in human nasal mucosa and assess their antigen-binding performance.
  • Administered two doses of an intranasal trivalent whole-virus inactivated influenza vaccine to human volunteers.
  • Collected nasal wash specimens to quantify monomeric, dimeric, and multimeric IgA fractions and evaluate virus-neutralizing titers.
  • Evaluated the binding and dissociation kinetics of nasal IgA fractions against recombinant trimeric influenza hemagglutinin using surface plasmon resonance.
  • Concentrations of multimeric IgA in nasal wash samples correlated positively with influenza virus-neutralizing antibody titers.
  • Surface plasmon resonance revealed that nasal fractions containing IgA multimers dissociated less from trimeric hemagglutinin than fractions lacking multimers, demonstrating tighter antigen adherence.

Cite This Study

Terauchi et al. (2018) studied this question.

synapsesocial.com/papers/6a9ff2eccda9ede4b85cc3b6https://doi.org/10.1080/21645515.2018.1438791
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