Clinical and Genetic Aspects of Coagulopathies

Article1 April 1965Clinical and Genetic Aspects of CoagulopathiesWith Special Emphasis on Generalized Intravascular ClottingFRITZ KOLLERFRITZ KOLLERSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-4-744 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBlood must fulfill two purposes that can be reconciled only with difficulty: It should remain fluid in order to assure the nutrition of the organs; and it must, in case of injuries, solidify rapidly in order to avoid a dangerous blood loss. Blood coagulation with its inhibitors and antagonists serves this double purpose. It is completed by additional mechanisms of hemostasis, that is, vascular and platelet reactions. The present report will discuss only the most extensively studied disorders of blood coagulation.CLOTTING FACTORSClinicians are often accused of having complicated excessively the simple coagulation scheme proposed by physiologists in the...References1. OERIMATTERISENSCHMIDHAUSERKOLLER JMHFF: Angeborener mangel an faktor V verbunden mit echter haemophilie A bie zwei brüdern. Modern Problems in Pediatrics I, Karger-Verlag, Basel, 1954, p. 575. Google Scholar2. GRAHAM JB: Biochemical genetics of blood coagulation. Amer. J. Hum. Genet. 8: 63, 1956. MedlineGoogle Scholar3. WRIGHT IS: The International Committee on Blood Clotting Factors—the past, present and future, in Fibrinogen and Fibrin, Transactions of the Conference of the International Committee on Blood Clotting Factors, Gleneagles, 1963. F. K. Schattauer, Stuttgart, 1964. Google Scholar4. KOLLER F: "Latente" Haemophilie und Diensttauglichkeit. Vjschr. Schweiz. Sanitaetsoffiz. 34: 183, 1957. MedlineGoogle Scholar5. HOESLEY GT: Der stammbaum der bluter von tenna. Arch. Klaus Stift. Vererbungsforsch 5: 303, 1930. Google Scholar6. MERSKEY C: Occurrence of hemophilia in human female. Quart. J. Med. 20: 299, 1951. MedlineGoogle Scholar7. CORNU P: A propos du déficit en facteur antihémophilique A dans la maladie de Willebrand. Proceedings of the Eighth Congress of the European Society of Haematology, Vol. II, Vienna. Karger, Basel, New York, 1961, p. 397. Google Scholar8. BACHMANN F: Familienuntersuchung beim kongenitalen Stuart-Prower factor-mangel. Arch. Klaus Stift. Verebungsforsch 23: 28, 1958. Google Scholar9. BACHMANNDUCKERTKOLLER FFF: Stuart-Prower factor assay and its clinical significance. Thromb. Diath. Haemorrh. 2: 24, 1958. MedlineGoogle Scholar10. KINGSLEY CS: Familial factor V deficiency; pattern of heredity. Quart. J. Med. 23: 323, 1954. MedlineGoogle Scholar11. ZOLLINGER W: Familienuntersuchung beim kongenitalen faktor VII-mangel. Arch. Klaus Stift. Vererbungsforsch 38: 6, 1963. Google Scholar12. KOLLER F: Importance of coagulopathies for genetics in general. Proc. Int. Soc. Haemat. (VIIth Congress) Rome, 1958. Google Scholar13. DUCKERTJUNGSHMERLING FED: A hitherto undescribed congenital haemorrhagic diathesis probably due to fibrin stablizing factor deficiency. Thromb. Diath. Haemorrh. 5: 179, 1960. MedlineGoogle Scholar14. BECKDUCKERTERNST EFM: The influence of fibrin stabilizing factor on the growth of fibroblasts. Thromb. Diath. Haemorrh. 6: 485, 1961. MedlineGoogle Scholar15. LOELIGER EA: Der holländische Thrombosedienst. Wien. Klin. Wschr. 73: 917, 1961. MedlineGoogle Scholar16. SIGGPESTALOZZICLAUSSKOLLER AHHF: Verstärkung der Antikioagulantienwirkung durch Butazolidin. Schweiz. Med. Wschr. 86: 1194, 1957. Google Scholar17. QUICKGEORGATSOSHUSSEY AJJGCV: The clotting activity of human erythrocytes: Theoretical and clinical implications. Amer. J. Med. Sci. 228: 207, 1954. CrossrefMedlineGoogle Scholar18. DES PREXHOROWITZHOOK RMHJEW: Effects of bacterial endotoxin on rabbit platelets. J. Exp. Med. 114: 857, 1961. CrossrefMedlineGoogle Scholar19. KRUCKEBOHLELASCH HJAHG: Klinik und histopathologie des menschlichen Sanarelli-Shwartzman phaenomens. Med. Hyg. (Geneve) 21: 1100, 1963. Google Scholar20. LASCHRODRIGNEZ-ERDMANNKRECKE HGFHJ: Quantitative und qualitative veranderungen der Thrombocyten beim Sanarelli-Schwartzman Phaenomen. Verh. Deutsch. Ges. Inn. Med. 66: 992, 1960. Google Scholar21. BETTEX-GOLLANDLÜSCHERSIMONVASSALLI MEFCP: Induction of viscous metamorphosis in human blood platelets by other means than by thrombin. Nature 200: 1109, 1963. CrossrefMedlineGoogle Scholar22. LÜSCHER EF: L'activation des enzymes proteolytiques du plasma sanguin. Med. Hyg. (Geneve) 21: 1113, 1963. Google Scholar23. KOLLER F: Intravsacular clotting and spontaneous fibrinolysis. Acta Haemat. (Basel) 31: 4, 239, 1964. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: FRITZ KOLLERAffiliations: Basel,From the University of Basel, Basel, Switzerland.This paper was presented as an honorary fellowship lecture before the Forty-fourth Annual Session of the American College of Physicians, April, 1963, in Denver, Colo.Requests for reprints should be addressed to Prof. Dr. Fritz Koller, University of Basel, Basel, Switzerland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNucleotide sequence of the plasminogen activator gene of Yersinia pestis: relationship to ompT of Escherichia coli and gene E of Salmonella typhimuriumA propos d'une observation de Méningococcie suraiguë avec Purpura fulminans chez le sujet âgéThe Role of Heparin in the Management of Consumption CoagulopathyThe Syndrome of Asplenia, Pneumococcal Sepsis, and Disseminated Intravascular CoagulationALAN L. BISNO, M.D., JOHN C. FREEMAN, M.D.Disseminated intravascular coagulationCoumarin-induced skin necrosis in a sixteen year old girlThe Clinical Significance of Necrosis of the SkinPathogenesis of plagueChanges in the fibrinolytic enzyme system following intravascular coagulation induced by thrombin and endotoxinTherapeutic implications of disseminated intravascular coagulationHemopoietic SystemDie ?abnorme? chirurgische BlutungA Guide to Disorders of HemostasisMEHRAN GOULIAN, M.D. 1 April 1965Volume 62, Issue 4Page: 744-756KeywordsBloodBlood coagulationClinical geneticsFellowshipsHemophilia AHemophilia BHemostasisNutritionPathogenesisPlatelets ePublished: 1 December 2008 Issue Published: 1 April 1965 PDF downloadLoading ...