Surreptitious Ingestion of Coumarin Anticoagulant Drugs

Article1 May 1966Surreptitious Ingestion of Coumarin Anticoagulant DrugsROBERT A. O'REILLY, M.D., F.A.C.P., PAUL M. AGGELER, M.D., F.A.C.P.ROBERT A. O'REILLY, M.D., F.A.C.P.Search for more papers by this author, PAUL M. AGGELER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-5-1034 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCoumarin and indanedione anticoagulant drugs are commonly used in the treatment of thromboembolic disorders. In addition, they have been used occasionally to accomplish murder (1), to commit suicide (2), or to produce factitious disease (3-7). Rarely, they have been dispensed in error by a pharmacist (8) or have been confused by the patient with other medications (8).Surreptitious ingestion of an anticoagulant should be suspected in patients who have an unexplained acquired hemorrhagic diathesis associated with low prothrombin complex activity. It should be thought of particularly in persons who have access to coumarin or indanedione compounds, either as medication or...References1. IKKALAMYLLYLÄNEVANLINNAPELKONENPYÖRÄLÄ EGHRRK: Haemorrhagic diathesis due to criminal poisoning with warfarin. Acta Med. Scand. 176: 201, 1964. CrossrefMedlineGoogle Scholar2. HOLMESLOVE RWJ: Suicide attempt with warfarin, a bishydroxycoumarin-like rodenticide. JAMA 148: 935, 1952. CrossrefMedlineGoogle Scholar3. STAFNEMOE WAAE: Hypoprothrombinemia due to dicumarol in a malingerer: case report. Ann. Intern. Med. 35: 910, 1951. LinkGoogle Scholar4. 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CATALDO FD: Acquired idiopathic hypoprothrombinemia. Acquired hypoprothrombinemia secondary to selective deficient absorption of vitamin K. Acta Haemat. (Basel) 34: 187, 1965. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT A. O'REILLY, M.D., F.A.C.P.; PAUL M. AGGELER, M.D., F.A.C.P.Affiliations: San Jose and San Francisco, CaliforniaFrom the Department of Medicine, Santa Clara County Hospital, San Jose, Calif., the Hematology Research Laboratory, Children's Hospital, and University of California Medical Service, San Franciso General Hospital, San Francisco, Calif.This work was supported by grants HE 02754, TI AM-5103, HE 08058, and IK 6 HE 021,835, U. S. Public Health Service, Bethesda, Md.Requests for reprints should be addressed to Robert A. O'Reilly, M.D., Chairman, Department of Medicine, Santa Clara County Hospital, 751 S. Bascom Ave., San Jose, Calif. 95128. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA non-canonical vitamin K cycle is a potent ferroptosis suppressorEvaluation of oral anticoagulants with vitamin K epoxide reductase in its native milieuFunctional Study of the Vitamin K Cycle Enzymes in Live CellsStructural and functional insights into enzymes of the vitamin K cycleAnticoagulant RodenticidesPhytonadione Therapy in a Multiple-Drug Overdose Involving WarfarinMunchausen syndrome in hematology: Case reports of three variants and review of the literatureExtreme Warfarin Intoxication Secondary to Possible Covert Drug IngestionLes maladies factices et le syndrome de MünchausenIntentional Poisoning of Two Siblings by Prescription DrugsPsychologic and Psychosocial Aspects of Medical Practice An Annotated BibliographyRUSSELL M. WILDER, M.D., F.A.C.P.Bleeding from Self-administration of Phenindione: a Detailed Case-studySurreptitious Ingestion of WarfarinBlutThe Liver and Blood Coagulation: Physiology and PathologyBlutHemorrhagic Diathesis Induced by Surreptitious Ingestion of Coumarin DrugsThe Anticoagulant Malingerer Psychiatric Studies of Three PatientsDAVID P. AGLE, M.D., OSCAR D. RATNOFF, M.D., F.A.C.P., GOTTFRIED K. SPRING, M.D.Hemorrhages In a Young Boy Due to Unsuspected Diphenadione (Didandin) IntoxicationGastrointestinal hemorrhage as a postoperative phenomenonHEREDITARY RESISTANCE TO COUMARIN ANTICOAGULANT DRUGS IN MAN AND RATHEREDITARY RESISTANCE TO COUMARIN ANTICOAGULANT DRUGS IN MAN AND RAT 1 May 1966Volume 64, Issue 5Page: 1034-1041KeywordsAnticoagulant therapyAnticoagulantsCoumarinsHospital medicineIngestionMedical servicesMotivationPharmacistsResearch laboratoriesSuicide ePublished: 1 December 2008 Issue Published: 1 May 1966 PDF downloadLoading ...