Total Syntheses of the Antibacterial Natural Product Abyssomicin C

Intra- or intermolecular: Abyssomicin C, isolated from a marine bacterium, is a potent polyketide-type antibiotic and a synthetic target of prime importance because it inhibits pathogenic bacteria. In recent independent syntheses by the Sorensen and the Nicolaou groups, intra- and intermolecular Diels–Alder reactions featured as the respective key steps for the construction of the oxabicyclo[2.2.2]octane core.