Key result
Phosphatidic acid applied to K(ATP) channels induced a novel pattern in gating kinetics, decreasing mean open time from 12.2 ms to 3.3 ms, distinguishing its effects from phosphatidylinositols.
Why the study?
Does phosphatidic acid modulate cardiac K(ATP) channels similarly to phosphatidylinositols?
Does phosphatidic acid modulate cardiac K(ATP) channels similarly to phosphatidylinositols?
Absolute Event Rate: 3.3% vs 12.2%
Phosphatidic acid modulates cardiac K(ATP) channels similarly to phosphatidylinositols but induces a novel pattern in gating kinetics, suggesting a common electrostatic mechanism with additional specific effects.
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Does not inform clinical K(ATP) modulation; leaves open distinct lipid-specific effects in cardiac channels.
Fan et al. (2003) studied this question. Phosphatidic acid (PA) vs. Phosphatidylinositols was evaluated on Mean open time of K(ATP) channels. Phosphatidic acid applied to K(ATP) channels induced a novel pattern in gating kinetics, decreasing mean open time from 12.2 ms to 3.3 ms, distinguishing its effects from phosphatidylinositols.
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