What question did this study set out to answer?

To evaluate the long-term prognostic impact of surgical resection, craniospinal irradiation, and cisplatin-based chemotherapy in patients with intracranial malignant non-germinomatous germ cell tumors.

March 1, 2004Klinische Pädiatrie

Impact of Surgery, Chemotherapy and Irradiation on Long Term Outcome of Intracranial Malignant Non-Germinomatous Germ Cell Tumors: Results of the German Cooperative Trial MAKEI 89

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To evaluate the long-term prognostic impact of surgical resection, craniospinal irradiation, and cisplatin-based chemotherapy in patients with intracranial malignant non-germinomatous germ cell tumors.
Analyzed 41 patients with intracranial malignant non-germinomatous germ cell tumors enrolled in the German prospective protocol MAKEI 89 between January 1989 and January 1994.
Compared outcomes between patients receiving protocol-directed therapy (n = 27) and non-protocol therapy (n = 14), with a median follow-up of 112 months for surviving patients.
Evaluated the therapeutic effects of surgical extent, craniospinal irradiation, and cumulative cisplatin dosage using chi-square, Fisher exact, and log-rank tests.
Five-year event-free survival was 0.59 ± 0.06 for protocol-treated patients (n = 27) versus 0.37 ± 0.33 for non-protocol patients (n = 14; p = 0.70), while 5-year relapse-free survival was 0.74 ± 0.06 versus 0.38 ± 0.33 (p = 0.14).
Craniospinal irradiation significantly prolonged survival (p = 0.035), as did a cumulative cisplatin dose ≥ 400 mg/m² (p = 0.002).
Extensive surgical resection (complete versus incomplete tumor resection) demonstrated no statistically significant impact on overall survival (p = 0.12).

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Implication

Prospective trial reveals that craniospinal irradiation and cisplatin improve survival in intracranial non-germinomatous germ cell tumors, suggesting extensive initial surgery may be avoided.

Cite This Study

Calaminus et al. (2004) studied this question.

synapsesocial.com/papers/6a9ffc3adfc81ffeb871e717 https://doi.org/10.1055/s-2004-822626

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Implication

Prospective trial reveals that craniospinal irradiation and cisplatin improve survival in intracranial non-germinomatous germ cell tumors, suggesting extensive initial surgery may be avoided.

Impact of Surgery, Chemotherapy and Irradiation on Long Term Outcome of Intracranial Malignant Non-Germinomatous Germ Cell Tumors: Results of the German Cooperative Trial MAKEI 89

Key Points

Discussion

Implication

Cite This Study

Impact of Surgery, Chemotherapy and Irradiation on Long Term Outcome of Intracranial Malignant Non-Germinomatous Germ Cell Tumors: Results of the German Cooperative Trial MAKEI 89

Key Points

Discussion

Implication

Cite This Study

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