Exploiting 1,3-dipolar cycloaddition and urea --> hydantoin cyclization transformations, novel spiro[cyclopenta[d]isoxazole-4',5-imidazolindine] heterocycles of generalized structure I have been prepared. The 1-amino-3-cyclopentenecarboxylate precursor II was prepared from a suitably activated/protected derivative of glycine and the bis-alkylating agent cis-1,4-dichloro-2-butene.
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Park et al. (1998) studied this question.
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