Key result
Initiation of glycopyrronium bromide in a 78-year-old female on chronic tamoxifen was associated with severe, transient QT prolongation (QTcF 603 ms) and syncope that resolved after drug cessation.
Case Report (n=1)
No
This case report highlights a potential risk of severe QT prolongation with glycopyrronium bromide in a real-world setting, particularly in patients on other medications like tamoxifen.
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May warrant QT monitoring with glycopyrronium in COPD; hypothesis-generating case report requiring confirmation before practice change.
Chiu et al. (2016) conducted a case report in QT prolongation (n=1). Glycopyrronium bromide was evaluated on QTc interval. Initiation of glycopyrronium bromide in a 78-year-old female on chronic tamoxifen was associated with severe, transient QT prolongation (QTcF 603 ms) and syncope that resolved after drug cessation.
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