Promoter Elements, Regulatory Elements, and Chromatin Structure of the Yeast his3 Gene

This paper deals with the relationship between the structure and function of a simple eukaryotic gene, the his3 gene of the baker's yeast Saccharomyces cerevisiae. First, I describe genetic experiments that define elements necessary for his3 expression (promoter elements) as well as elements responsible for regulating the level of expression as a function of the cell's physiological state (regulatory elements). Second, I discuss the relationship between these genetic elements and the chromatin structure of the his3 gene.