Key result
Low dose aspirin (4 mg/kg) peroperatively did not markedly affect bleeding-times or patency rates in microarterial anastomoses, but initially increased in vivo platelet accumulation (p<0.05).
Why the study?
Does low-dose aspirin prevent in vivo platelet accumulation at microarterial anastomotic sites in a rabbit model?
Population
15 rabbits
Comparison
Aspirin 4 mg/kg given as a single intraaortical… vs Control group (no aspirin)
Design
Preclinical
Follow-up
Up to 4 hours
Authors
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Low-dose aspirin does not curb early platelet accumulation in rabbit microanastomoses; leaves open its perioperative role in clinical microsurgery.
Does low-dose aspirin prevent in vivo platelet accumulation at microarterial anastomotic sites in a rabbit model?
p-value: p=<0.05
Low-dose aspirin peroperatively does not prevent initial in vivo platelet accumulation at microarterial anastomoses in rabbits, but may promote subsequent platelet disaggregation.
Wieslander et al. (1990) studied Microarterial anastomoses (n=12). Low Dose ASA (Aspirin) vs. Control was evaluated on In vivo platelet accumulation, bleeding-times, and patency (p=<0.05). Low dose aspirin (4 mg/kg) peroperatively did not markedly affect bleeding-times or patency rates in microarterial anastomoses, but initially increased in vivo platelet accumulation (p<0.05).
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