A new cyclic lipopeptide, marihysin A (1), along with the three known cyclodipeptides cyclo(Ala‐Ile) (2), cyclo(Ala‐Leu) (3), and cyclo(Ala‐Tyr) (4), was isolated from the fermentation broth of the marine microorganism Bacillus marinus B‐9987 isolated from the tissues of rhizophere of Suaeda salsa in the intertidal zone of the Bohai Bay of P. R. China. Marihysin A (1) was established to be cyclo(Pro‐Gln‐Asn1‐Ser‐Asn2‐Tyr‐Asn3‐β‐aminotetradecanoic acid) by spectroscopic analysis, and it exhibits broad‐spectrum but low activity against plant pathogens as determined by antifungal bioassay.
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Liu et al. (2010) studied this question.
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