Key result
A mathematical model incorporating the electrogenic Na/K pump demonstrates that membrane voltage lowers internal chloride concentration to make osmotic room for vital sequestered substances.
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An equation for membrane voltage is derived that takes into account the electrogenicity of the Na/K pump and is valid dynamically, as well as in the steady state. This equation is incorporated into a model for the osmotic stabilization of cells. The results emphasize the role of the pump and membrane voltage in lowering internal Cl(-) concentration, thus making osmotic room for vital substances that must be sequestered in the cell.
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Clay M. Armstrong (2003) studied Osmotic stabilization of cells. Mathematical modeling was evaluated. A mathematical model incorporating the electrogenic Na/K pump demonstrates that membrane voltage lowers internal chloride concentration to make osmotic room for vital sequestered substances.
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