Rapid Construction of the [6‐6‐6‐5] Tetracyclic Skeleton of the Daphniphyllum Alkaloid Daphenylline

This is the authors' abstract. We don't add key points for this paper.

You can call me Al: A concise route for construction of the [6-6-6-5] tetracyclic skeleton of daphenylline, a structurally novel Daphniphyllum alkaloid, has been developed with full stereocontrol in only 8 steps from two known fragments. This approach features an intramolecular [3+2] cycloaddition of a 2-azaallyl anion with an alkene to form the cis-fused AC rings.