Evaluation of A-ring fused pyridine d -modified androstane derivatives for antiproliferative and aldo–keto reductase 1C3 inhibitory activity

also has selective submicromolar antiproliferative activity against HT-29 colon cancer cells. None of the new derivatives have affinity for estrogen or androgen receptors in a yeast screen, suggesting negligible estrogenicity and androgenicity. Combined, our results suggest that A-ring pyridine fusions have potential in modulating the anticancer activity of steroidal compounds.