Key result
Using the Dutch Pediatric Intensive Care Evaluation registry, the overall incidence of late intracranial vitamin K deficiency bleeding was 2.1 per 100,000 live births, identifying more cases than general surveillance.
Observational (n=64)
Yes
Pediatric intensive care registries provide a more complete and reliable method for monitoring the incidence of late intracranial vitamin K deficiency bleeding compared to general surveillance.
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PICU registries may yield more complete late intracranial VKDB incidence data than general surveillance; leaves open whether this approach should guide public health monitoring.
AIM: To determine the incidence of late intracranial vitamin K deficiency bleeding (VKDB) in The Netherlands using the Dutch Pediatric Intensive Care Evaluation (PICE) registry. METHODS: The PICE registry was used to identify all infants who were admitted to a Dutch pediatric intensive care unit (PICU) with intracranial bleeding between 1 January 2004 and 31 December 2007. Cases of confirmed late intracranial VKDB were used to calculate the incidence for each year. To estimate the completeness of ascertainment of the PICE registry, data from 2005 were compared with general surveillance data from that year. RESULTS: In the 4-year study period, 16/64 (25%) of the infants admitted with intracranial bleeding had late intracranial VKDB, resulting in an overall incidence of 2.1/100,000 live births (95% confidence interval 1.2-3.5). The single-year incidence varied markedly between 0.5 and 3.3 per 100,000 live births. All five ascertained cases in 2005 were identified using the PICE registry, while general surveillance identified only three. CONCLUSIONS: The PICE registry allows ongoing monitoring of the incidence of late intracranial VKDB and appears to be associated with a higher rate of completeness than general surveillance. We propose the use of pediatric intensive care registries to assess the efficacy of national vitamin K prophylactic regimens.
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Visser et al. (2011) conducted an observational in Intracranial bleeding / Late vitamin K deficiency bleeding (VKDB) (n=64). Pediatric Intensive Care Evaluation (PICE) registry ascertainment vs. General surveillance was evaluated on Overall incidence of late intracranial VKDB per 100,000 live births (95% CI 1.2-3.5). Using the Dutch Pediatric Intensive Care Evaluation registry, the overall incidence of late intracranial vitamin K deficiency bleeding was 2.1 per 100,000 live births, identifying more cases than general surveillance.
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