The idea of applying the ratio of 3γ and 2γ positron annihilation rate as a diagnostic indicator in the PET imaging is proposed.It is based on the fact that the 3γ annihilation is related to the decay rate of triplet state of positronium atoms produced inside the human body during the PET imaging, and it reflects the size and the concentration of free volumes present in the investigated tissues.The tissues deformation related to the cancerous changes are expected to influence the local value of the 3γ fraction.
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Jasińska et al. (2017) studied this question.