This review summarizes recent studies with 5-hydroxytryptamine 2A (5-HT 2A ) receptors, which represent the major site of action of hallucinogens and a likely site for atypical antipsychotic drug actions. We present evidence demonstrating that atypical antipsychotic drugs, as a group, have a preferentially high affinity for 5-HT 2A receptors, compared with their affinities for other neurotransmitter receptors. The 5-HT 2A receptor blockade seen with atypical antipsychotic drugs is probably an essential factor in explaining many of the unique features of atypical antipsychotic drugs. Atypical antipsychotic drugs have high affinities for several other 5-HT receptors (5-HT 2C , 5-HT 6 , and 5-HT 7 ), and the potential role of these novel 5-HT receptors in atypical antipsychotic drug action is also summarized.
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Roth et al. (1999) studied this question.
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