‘Rhaz'zmatazz: A total synthesis of (−)-rhazinilam and the first asymmetric total synthesis of (−)-rhazinicine were accomplished by using constructing the indolizinone core through the gold-catalyzed cyclization of a fully elaborated linear ynamide. The scope and generality of this cascade reaction for the construction of highly substituted indolizinones were also investigated.
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Sugimoto et al. (2013) studied this question.
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