Synthesis of 1-Deoxynojirimycin and N-Butyl-1-deoxynojirimycin

All articles of this category 1-Deoxynojirimycin ( 1 ) is a natural alkaloid with several biological activities; the analog N -butyl-1-deoxynorjirimycin ( 4 ), for example has shown potent anti HIV-1 and HIV-2 activity without cytotoxicity. As part of a program to synthesize compounds with biological activity against retroviruses, we developed an efficient route for the preparation of 1 and 4 employing as raw material glucose and other inexpensive reagents. alkaloids - biological activity - synthesis