Synthetic study demonstrates efficient assembly of a platensimycin tetracyclic intermediate from carvone, suggesting a practical route toward broad-spectrum antibiotics.
Extensive pharming: An expedient entry into the tetracycle 2, a late-stage synthetic intermediate en route to the broad-spectrum antibiotic (−)-platensimycin (1) has been accomplished. The strategy involves a series of cyclizations starting from the inexpensive chiral pool starting material (R)-(−)-carvone.
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Nicolaou et al. (2008) studied this question.
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