Getting out of the way: In fluorinated cyclododecane structures the CF2 group locates only at corner positions (see picture). This relaxes 1,4-H,H transannular interactions as a result of C-CF2-C angle widening. Misplaced CF2 groups lead to significant ring distortion. It follows that strategic incorporation of CF2 groups has potential as a design feature to introduce order and polarity into organic hydrocarbon structures.
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Skibiński et al. (2011) studied this question.
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