The main risk factors for breast cancer can be usefully grouped into four major categories-family history/genetic, reproductive/hormonal, proliferative benign breast pathology, and mammographic density. These factors are briefly reviewed and quantitative estimaters of risk are given. A computer programme for combining them to produce individualized risk profiles is described. The ongoing IBIS-II trial of chemoprevention for high risk postmenopausal women is presented as one approach to managing high risk women.
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Jack Cuzick (2003) studied this question.
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